Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BARI, A. S. M.
Right arrow Articles by BENNETT, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BARI, A. S. M.
Right arrow Articles by BENNETT, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 British Society for Rheumatology

other

ANTI-TYPE II COLLAGEN ANTIBODY IN NATURALLY OCCURRING CANINE JOINT DISEASES

A. S. M. BARI, S. D. CARTER, S. C. BELL, K. MORGAN and D. BENNETT

Arthritis Research Croup, Departments of Veterinary Pathology & Veterinary Clinical Science, University of Liverpool Liverpool Department of Rheumatology, University of Manchester Medical School

Correspondence to: Correspondence to Dr. S. D. Carter, Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX.

Autoimmunity to collagen was investigated in several naturally occurring arthropathies of the dog. Increased levels of serum anti-native collagen type II antibody, as assessed by ELISA, were shown in 72.4% of dogs with rheumatoid arthritis (RA), 88% of dogs with infective arthritis (IA) and 52% of dogs with osteoarthritis (OA) (p<<0.001). The mean levels of antibody in cruciate disease patients (CR) were also significantly increased compared to control dogs (p<<0.01). Serum anti-collagen antibody in OA dogs correlated with that in precipitated serum immune complexes. There was also a correlation between anti-collagen antibody level in synovial fluid and in synovial fluid complexes in dogs with rupture of the cranial cruciate ligament. In all patient groups, collagenase digestion of polyethylene glycol (PEG) precipitates from sera and synovial fluids caused a significant rise in specific antibody levels to collagen, indicating the presence of collagen-anti-collagen complexes in all arthropathies. In dogs with RA, the levels of collagen-specific antibody in synovial fluid complexes correlated with the total IgG in these complexes. These findings implicate collagen-anti-collagen complexes in the pathogenesis of naturally occurring joint diseases in the dog, but they are unlikely to be the primary aetiological mechanism.

KEY WORDS: ELISA, Collagen antibodies, Canine rheumatoid arthritis, Canine osteoarthritis, Canine infective arthritis, Immune complexes, Autoimmunity


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
J. Beren, S. L. Hill, M. Diener-West, and N. R. Rose
Effect of Pre-Loading Oral Glucosamine HCl/Chondroitin Sulfate/Manganese Ascorbate Combination on Experimental Arthritis in Rats
Experimental Biology and Medicine, February 1, 2001; 226(2): 144 - 151.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.