Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by JONSSON, H.
Right arrow Articles by JONSON, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JONSSON, H.
Right arrow Articles by JONSON, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 British Society for Rheumatology

other

LUNG FUNCTION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND PERSISTENT CHEST SYMPTOMS

H. JONSSON*,, O. NIVED*, G. STURFELT*, S. VALIND{dagger} and B. JONSON{dagger}

*Departments of Rheumatology, University Hospital Lund, Sweden
{dagger}Departments of Clinical Physiology, University Hospital Lund, Sweden

Correspondence to: Correspondence to Dr. Helgi Joosson, Department of Rheumatology, 221 85 Lund, Sweden.

Twelve consecutive patients with systemic lupus erythematosus (SLE) and chest symptoms of at least 3 months' duration were investigated with spirometry, lung mechanics at rest and exercise, diffusion apacity and right heart catheterization. Vital capacity (88% of predicted, p<<0.05), and FEV1 (84%, p<<0.01) were decreased in the study group, but spirometric and diffusion capacity abnormalities were moderate compared with previous studies. The single breath CO2 test showed, in six patients, ventilation-perfusion mismatch with patterns typical for either bronchia] obstruction or vascular disease. Non-respiratory factors were responsible for reduction of working capacity (on average 68% of predicted normal values (p<<0.001)). Two patients with pulmonary hypertension were identified by right heart :atheterization. One of them had overlap features with the CREST syndrome. Both these patients had abnormal SBT-CO2 test and diffusion capacity, along with diffuse perfusion defects on perfusion scintigraphy.

The low frequency of pulmonary function abnormalities in this study suggests that irreversible pulmonary damage is uncommon in SLE.

KEY WORDS: SLE, Perfusion, Ventilation, Pulmonary hypertension


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
A.M. Bertoli, L.M. Vila, M. Apte, B.J. Fessler, H.M. Bastian, J.D. Reveille, and G.S. Alarcon
Systemic lupus erythematosus in a multiethnic US Cohort LUMINA XLVIII: factors predictive of pulmonary damage
Lupus, June 1, 2007; 16(6): 410 - 417.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.