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© 1989 British Society for Rheumatology

other

SJÖGREN'S SYNDROME: ASSOCIATION WITH TYPE-1 DIABETES MELLITUS

A. BINDER, P. J. MADDISON*, P. SKINNER*, A. KURTZ{dagger} and D. A. ISENBERG

{dagger}The Bloomsbury Rheumatology Unit and the Department of Rheumatology Research and the Department of Medicine
*University College and the Middlesex Hospital Medical School LondonThe Royal National Hospital for the Rheumatic Diseases Bath

Correspondence to: Correspondence to Dr. Isenberg, Bloomsbury Rheumatology Unit, Arthur Stanley House, 40-50 Tottenham Street, London W1P 9PG.

This study of 102 unselected type-1 diabetic patients has shown that sicca symptoms affect 55% of the patients, although sometimes only during hyperglycaemic phases. While these symptoms might be attributable to the diabetes, the frequency of antinuclear antibodies in those suspected of having Sjögren's (25% by HEp-2) and particularly anti-Ro antibodies (32% by ELISA) reinforces the suspicion that Sjogren's syndrome may underlie their presence.

KEY WORDS: Sicca syndrome, Autoantibodies, Anti-Ro, Hyperglycaemia, Immunoglobulins, Rheumatoid factor


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