Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by RIDLEY, M. G.
Right arrow Articles by PANAYI, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by RIDLEY, M. G.
Right arrow Articles by PANAYI, G. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 British Society for Rheumatology

research-article

MONOCYTE ACTIVATION IN RHEUMATOID ARTHRITIS: EVIDENCE FOR IN SITU ACTIVATION AND DIFFERENTIATION IN JOINTS

M. G. RIDLEY*, G. KINGSLEY, C. PITZALIS and G. S. PANAYI

Rheumatic Diseases Unit, Department of Medicine, Guy's Hospital, United Medical and Dental Schools London SE1 9RT

Correspondence to: Correspondence to G. Panayi.

Monocytes, defined by staining with the Mo-2 and Leu-M3 monoclonal antibodies which both detect the CD14 antigen, were studied in peripheral blood of control subjects and patients with rheumatoid arthritis as well as in rheumatoid synovial fluid of the latter for expression of activation/differentiation markers. The monocytes in the rheumatoid synovial fluids showed increased expression of class II major histocompatibility antigens (HLA-DR and -DQ) and decreased positivity for the peanut agglutinin receptor as compared with those from patient and control peripheral blood. There were no differences in phenotype between the control and patient peripheral blood monocytes. These findings are consistent with the hypothesis that monocytes are activated and differentiate into more mature macrophage-like cells after entry into the rheumatoid joint.

KEY WORDS: Class II MHC antigens, Peanut agglutination, Gamma interferon

*Present address: Department of Rheumatology, St Thomas' Hospital, London SE1.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Lucas, X. Zhang, V. Prasanna, and D. M. Mosser
ERK Activation Following Macrophage Fc{gamma}R Ligation Leads to Chromatin Modifications at the IL-10 Locus
J. Immunol., July 1, 2005; 175(1): 469 - 477.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.