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© 1990 British Society for Rheumatology

other

INCREASED APOTRANSCOBALAMIN II LEVELS IN RHEUMATOID ARTHRITIS

F. ARNALICH, Autonomous Faculty of Medicine*,, A. F. ZAMORANO{dagger}, S. BENITO-URBINA{ddagger}, J. GIJÓN-BAÑOS{ddagger}, E. DE MIGUEL{ddagger}, J. M. PENA and J. J. VÁZQUEZ*

*Department of Medicine, La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain
{dagger}Division of Haematology, La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain
{ddagger}Division of Rheumatology Unit, La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain
La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain

Correspondence to: Correspondence to Dr F. Arnalich, Hospital La Paz. Resid. General, Planta 10, Paseo de la Castellana 261, 28046 Madrid, Spain

The distribution of endogenous cobalamin among serum cobalamin-binding proteins was studied in 30 patients with active rheumatoid arthritis (RA) and 27 in clinical remission

The mean total serum cobalamin concentration (holo-transcobalamin I and II) was similar in both groups of patients, whereas mean apotranscobalamin II was significantly increased in patients with active RA. The clinical significance of this finding is not yet established but it might be a useful parameter for the evaluation of disease activity in RA

KEY WORDS: Rheumatoid arthritis, Serum cobalamin-binding proteins, Apotranscobalamin II, Vitamin B12 binding proteins


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