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© 1990 British Society for Rheumatology

brief-report

FAILURE OF SELENIUM-ACE TO IMPROVE OSTEOARTHRITIS

J. HILL and H. A. BIRD

Clinical Pharmacology Unit (Rheumatism Research), Royal Bath Hospital Cornwall Road, Harrogate HG1 2PS, UK

Correspondence to: Correspondence to Dr H. Bird

Selenium-ACE, a formulation containing the trace element selenium with three vitamins, is widely promoted for the treatment of arthritis. A controlled double-blind trial of Selenium-ACE in osteoarthritis failed to demonstrate any significant efficacy for the compound over placebo at 3 or 6 months though there was a non-significant trend to improvement in some clinical parameters in both groups. Side-effects were more frequently seen in the placebo group

KEY WORDS: Trace element, Vitamin A, Vitamin C, Vitamin E controversy, Controlled study, Arthritis


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