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© 1990 British Society for Rheumatology

other

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, HIATUS HERNIA, AND HELICOBACTER PYLORI, IN PATIENTS WITH OESOPHAGEAL ULCERATION

T. M. SHALLCROSS1, J. I. WYATT*, B. J. RATHBONE and R. V. HEATLEY

Departments of Medicine, St James's Hospital Leeds LS9 7TF
*Departments of Pathology, St James's Hospital Leeds LS9 7TF

Correspondence to: 1Correspondence to Dr T. Shallcross.

The frequency of oesophageal ulceration in 55 patients undergoing endoscopy for dyspeptic symptoms and who had recently used NSAIDs was studied, and compared with 86 patients seen in the same clinic who had not recently used these drugs. Oesophageal ulceration was significantly more common in those who had used NSAIDs (P = 0.012), and also showed a highly significant association with the presence of a hiatus hernia (P<0.001). No association was found between the presence of gastric Helicobacter pylori and either oesophageal ulceration or histological oesophagitis. Patients receiving NSAIDs, especially those with a hiatus hernia, are at risk of oesophageal ulceration and presumably subsequent stricture formation. This should be borne in mind when prescribing these agents.

KEY WORDS: Anti-inflammatory drugs, Non-steroidal, Oesophagus, Oesophagitis, Oesophageal ulcer, Peptic ulcer, Stricture, Helicobacter pylori, Hiatus hernia


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