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© 1990 British Society for Rheumatology

other

ESTIMATION OF SERUM Vicfflb LIGHT CHAINS IN RHEUMATOID ARTHRITIS AND CORRELATION WITH CD5-POSITIVE -CELLS

HELEN B. SMALLEY*, JANET TODD*, R. M. R. BARNES*, R. N. THOMPSON{dagger}, G. N. ABRAHAM{ddagger} and P. M. JOHNSON*,

*Department of Immunology, University of Liverpool Fazakerley Hospital, Liverpool
{dagger}Department of Rheumatology Fazakerley Hospital, Liverpool
{ddagger}Department of Medicine, University of Rochester Medical Centre Rochester, NY, USA

Correspondence to: Correspondence to Professor P. M. Johnson, Department of Immunology, University of Liverpool, P0 Box 147, Liverpool L693BX.

The presence of Vidllb light chains in the sera of rheumatoid arthritis (RA) patients has been evaluated by an enzyme-linked immunosorbent assay (ELISA). V{kappa}IIIb light chains have been confirmed to be largely restricted to IgM, and were rarely detected in the IgG fraction of sera. The concentration of total serum VicIIIb did not significantly vary with age, nor did it correlate with IgM-rheumatoid factor (RF) titre. Although total serumV{kappa}IIIb was not significantly increased in RA patients compared with matched controls, IgM-RFs frequently contained VicIIIb. Using flow cytometry, CD5-positive B-cells were not increased in these RA patients compared with healthy laboratory control personnel. Furthermore, there was no direct correlation between total serum IgM VKlllb content and CD5-positive B-cell numbers in peripheral blood

KEY WORDS: VkIIIb light chains, Rheumatoid factor (RF), CD5-positive B-cells, Rheumatoid arthritis


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