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© 1990 British Society for Rheumatology

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IMMUNOGENETICS OF POLYMYALGIA RHEUMATICA

L. I. SAKKAS, N. LOQUEMAN, G. S. PANAYI, A. B. MYLES* and K. I. WELSH

Molecular Immunogenetics and Rheumatology Units, Division of Medicine, UMDS Guy's Hospital, London
*Department of Rheumatology St Peters Hospital, Chertsey, Surrey

Correspondence to: Correspondence to Dr K. Welsh, Molecular Immunogenetics, 18th Floor Tower, Guy's Hospital, London SE1 9RT

Evidence suggests that polymyalgia rheumatica (PMR) may be an immune-mediated disease. Therefore, the role of HLA class II genes, the switch region of immunoglobulin µ and {alpha} heavy chain as well as the T-cell receptor (TcR) genes were investigated by Southern blot analysis. The frequency of DR4 specificity was increased in PMR (67.4% versus 30.3%; P = 0.00017). No association was found with the DQA and DQB genes, the switch region of immunoglobulin µ and {alpha}1 heavy chain genes, and the TcR a, B and y genes. This study suggests that HLA-DR4 is an important susceptibility factor for PMR. Further studies are needed to elucidate the role of Ig and TcR genes

KEY WORDS: HLA, Immunoglobulin heavy chain genes, T-cell receptor genes, Southern blot


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