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© 1990 British Society for Rheumatology

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PATIENTS WITH ARTHRITIS AND ANTI-U1-RNP ANTIBODIES: A 10-YEAR FOLLOW-UP

H. I. PIIRAINEN

Kivelä Municipal Hospital, Helsinki, Finland

Correspondence to: Correspondence to Heikki Piirainen MD, Taulutie 1A3, SF-00680 Helsinki, Finland

Five hundred and forty patients attending a rheumatology ward were screened for antinuclear antibodies (ANA) by indirect immunofiuorescence (IFL). Seventy had a significant titre of ANA. Twenty-three had Ul-ribonucleoprotein antibodies (Ul-RNP-ab). The clinical findings in Ul-RNP-ab-positive patients were consistent with mixed connective tissue disease (MCTD). Disease was more serious in the Ul-RNP-ab-positive patients in terms of polyarthritis severity as well as mortality due to rheumatic disease. Thus, in this arthritis patient population, Ul-RNP-ab positivity predicted an aggressive disease characterized by an erosive arthritis

KEY WORDS: Ribonucleoprotein antibodies, Antinuclear antibodies, Mixed connective tissue disease, Rheumatoid arthritis


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