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© 1990 British Society for Rheumatology

other

THE INHIBITION OF NK CELL FUNCTION BY AZATHIOPRINE DURING THE TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS

REGINA CSEUZ and G. S. PANAYI

Rheumatology Unit, Division of Medicine, United Medical and Dental Schools Guy's Hospital, London SE1 9RT

Correspondence to: Correspondence to Professor G. Panayi

Treatment with azathioprine of patients with rheumatoid arthritis leads to a dramatic reduction in the 4 h NK cytotoxicity against K562 cells. The 24 h cytotoxicity against K562 and U937 cells, however, remains intact. The generation of cell-free supernatant cytotoxic factor(s) after incubating non-adherent mononuclear cells with U937 cells for 24 h is similar in the azathioprine patients and the controls. A large part of this supernatant cytotoxicity is due to tumour necrosis factor a which can be inhibited by a specific monoclonal antibody. The mechanism of the reduced 4 h NK cytotoxicity remains unknown but is probably not related to the anti-inflammatory properties of azathioprine

KEY WORDS: Cytotoxicity, Tumour necrosis factor a, Rheumatoid arthritis, Azathioprine


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