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© 1990 British Society for Rheumatology

brief-report

RACIAL VARIATION IN SERUM CREATINE KINASE UNRELATED TO LEAN BODY MASS

J. G. WORRALL*,, V. PHONGSATHORN*, R. J. L. HOOPER{dagger} and ELISABETH W. PAICE*

*Departments of Rheumatology Whittington Hospital, Highgate Hill, London N195NF
{dagger}Departments of Chemical Pathology Whittington Hospital, Highgate Hill, London N195NF

Correspondence to: Correspondence to Dr J. Worrall, Bloomsbury Rheumatology Unit, Middlesex Hospital, Arthur Stanley ,Tottenham street, London W1P 9PG

In a group of 30 black and 30 white healthy hospital workers, matched for age, sex and body weight, serum creatine kinase was significantly higher in black males than in white males (P>0.01). Seventeen blacks but only four whites had levels above the accepted upper limit of normal of 195 IU/1. There was no correlation with lean body mass. Elevation of serum creatine kinase need not signify disease in blacks, for whom a separate reference range should be established

Two cases are reported of physically healthy black men subjected to unnecessary investigation on the basis of persistently elevated serum creatine kinase

KEY WORDS: Creatine kinase, Muscle, Racial variation


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