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© 1990 British Society for Rheumatology

other

INTESTINAL FLORA OF PATIENTS WITH RHEUMATOID ARTHRITIS: INDUCTION OF CHRONIC ARTHRITIS IN RATS BY CELL WALL FRAGMENTS FROM ISOLATED EUBACTERIUM AEROFACIENS STRAINS

A. J. SEVERIJNEN, J. KOOL, A. J. G. SWAAK* and M. P. HAZENBERG

Department of Immunology, Erasmus University Rotterdam P. O. Box 1738, 3000 DR Rotterdam, The Netherlands
* Departnent of Rheumatology, Dr Daniel den Hoed Clinic Rotterdam, The Netherlands

Correspondence to: Correspondence to Dr A. Severijnen

The composition of the obligate anaerobic intestinal flora of patients with rheumatoid arthritis (RA) differed from that of healthy subjects (HS). Total numbers of aerobes as well as anaerobic coccoid rods were found elevated when compared with HS. Eubacterium species were found in all stool samples of both groups; Bifidobacterium species were present in seven (RA) and eight (HS) out of 10 subjects. From the flora of two RA patients and two HS Eubacterium species were iso lated and identified. Cell wall fragments from four E. aerofaciens strains (two from RA, two from HS) were tested for arthritis induction in rats. All four strains induced chronic arthritis which was histologically confirmed. We concluded that in the normal intestinal flora of RA patients Eubacterium species are present in high numbers (i.e. >109/g faeces); cell walls from isolated E. aerofaciens strains had arthropathic properties.

KEY WORDS: Arthritis, Faecal flora, Aerobes, Anaerobes, Coccoid rods, Eubacterium, Rat


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