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© 1990 British Society for Rheumatology

brief-report

THE LACK OF RELATIONSHIP BETWEEN ACETYLATOR PHENOTYPE AND IDIOPATHIC SYSTEMIC LUPUS ERYTHEMATOSUS IN A SOUTH-EAST ASIAN POPULATION: A STUDY OF INDIANS, MALAYS AND MALAYSIAN CHINESE

MEI LIN ONG{dagger}, T. G. K. MANT*,, K. VEERAPEN{dagger}, D. FITZGERALD*, FLORENCE WANG{dagger}, M. MANIVASAGAR{dagger} and J. J. BOSCO{dagger}

{dagger}Department of Medicine, University of Malaysia Kuala Lumpur, Malaysia
*Guy's Hospital London

Correspondence to: Correspondence to Dr T. Mant, Guy's Drug Research Unit, 6 Newcomen Street, London SEI 1YR

An association of idiopathic systemic lupus erythematosus (ISLE) with genetically determined N-acetylation polymorphism has been suspected from previous studies, mainly on Caucasian populations in which there is an approximate incidence of 50% of slow and rapid acetylators.

The present study is of the incidence of ISLE and acetylator status in a mixed population of Malaysia.

The results did not support an association between ISLE and acetylator status: the frequencies of slow acetylators in the ISLE patients who were Malaysian Chinese and Malay were 13 and 38% respectively. This did not differ significantly from the respective healthy groups (20 and 29%). The small number of Indians in the survey did not allow a valid comparison, but the figures did suggest a lack of association between ISLE and acetylator status.

KEY WORDS: Acetylator phenotype, Idiopathic systemic lupus erythematosus, South East Asian population


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