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© 1990 British Society for Rheumatology

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STREPTOCOCCAL ANTIBODY CROSS-REACTIVITY WITH HLA-DR4+VE B-LYMPHOCYTES. BASIS OF THE DR4 ASSOCIATED GENETIC PREDISPOSITION TO RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE?

C. RAJAPAKSE, S. AL BALLA, A. AL-DALLAN and H. KAMAL

King Khalid University Hospital, King Saud University Riyadh, Saudi Arabia

Correspondence to: Correspondence to Dr Chula Rajapak, Wellington Regional Rheumatic Diseases Centre, Hutt Hospital, Private Bag, Lower Hutt, New Zealand

B-lymphocytes obtained from patients with either rheumatic fever or rheumatic heart disease and from normal subjects were reacted with serum obtained from rabbits immunized with streptococcal cell wall antigen. The presence of cytotoxicity was sought using an inverted phase microscope after differential uptake of eosin dye. The serum was found to be significantly more cytotoxic to HLA-DR4 containing cells of both patients and normals compared with DR4 negative cells (P<0. 0001).

KEY WORDS: Streptococcal cell wall antigen, Antiserum, Cytotoxicity


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