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© 1991 British Society for Rheumatology

other

DEFECTS OF THE RETINAL PIGMENT EPITHELIUM IN SCLERODERMA

A. KRAUS, G. GUERRA-BAUTISTA, G. ESPINOZA, E. BAROJAS, H. QUIROZ-MERCADO, G. SANCHEZ-ECHEVERRI and D. ALARCON-SEGOVIA

Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán and the Asociación para Evitar la Ceguera en Mexico Mexico City, Mexico

Correspondence to: Correspondence to Dr Donato Alarcón-Segovia, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000 Mexico D.F., Mexico

We completed ocular examination, including retinal fluoroangiography, in 19 unselected patients with diffuse systemic sclerosis (scleroderma) and compared the findings with those made in 50 consecutive patients with systemic lupus erythematosus, 18 with primary Sjögren's syndrome, 20 with mixed connective tissue disease, and 20 healthy women. Five of 19 scleroderma patients had atrophy of the retinal pigment epithelium (26.3%) while none of the controls and only four of the 88 (4.5%) patients with other connective tissue diseases (P<0.01) had this anomaly. Atrophy of the pigmented epithelium of the retina may occur in scleroderma as a result of damage of the choroidal plexus.

KEY WORDS: Scleroderma, Retinal involvement, Retinal pigment epithelium atrophy


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