Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HORDON, L. D.
Right arrow Articles by COOPER, E. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HORDON, L. D.
Right arrow Articles by COOPER, E. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 British Society for Rheumatology

other

RENAL TUBULAR DYSFUNCTION IN RHEUMATIC DISEASES

L. D. HORDON, H. A. BIRD and E. H. COOPER

Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, HG1 2PS, and the Diagnostic Development Unit, University of Leeds Leeds

Correspondence to: Correspondence to Dr H. Bird

Evidence of renal tubular dysfunction as defined by abnormal urinary levels of {alpha} and ß2 microglobulin with or without microalbuminuria was found in 47 (16.5%) of 285 patients with a variety of rheumatic diseases, compared with a preva lence of <1% in 500 healthy adults. Previous work from this unit has shown a prevalence of tubular dysfunction of 24% in patients with severe rheumatic disease admitted to hospital, probably associated with severe rheumatoid arthritis. Although our study confirms a high prevalence of renal tubular dysfunction, we have shown that it is related to age and intercurrent illness, particularly urinary tract infection, rather than to rheumatic disease or drug therapy, although it is possible drug therapy could add to a compound insult on an ageing or damaged kidney.

KEY WORDS: Renal tubular dysfunction, {alpha}1microglobulin, ßmicroglobulin, Rheumatoid arthritis, Gold, Penicillamine, Non-steroidal anti-inflammatory drugs


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
G. D. Kitas and N. Erb
Reply: Microalbuminuria: is it a predictor of ischaemic heart disease in rheumatoid arthritis?
Rheumatology, April 1, 2004; 43(4): 538 - 538.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.