Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MUNIAIN, M. A.
Right arrow Articles by NARANJO, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MUNIAIN, M. A.
Right arrow Articles by NARANJO, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 British Society for Rheumatology

brief-report

CIRCADIAN VARIATIONS IN THE SUPEROXIDE PRODUCTION, ENZYME RELEASE AND NEUTROPHIL AGGREGATION IN PATIENTS WITH RHEUMATOID ARTHRITIS AND CONTROLS

M. A. MUNIAIN, M. D. RODRÍGUEZ, A. ROMERO, R. MATA, C. VARGAS and A. NARANJO

Department of Internal Medicine, Hospital Universitario ‘Virgen Macarena’, Avda Dr Fedriani s/n 41009 Sevilla, Spain

Correspondence to: Correspondence to Prof. M. Muniain.

Patients with rheumatoid arthritis (RA) experience fluctuations of symptoms throughout the day. These could be due to mechanical changes or modification of the inflammatory mechanisms.

In the present paper we studied fluctuations of superoxide production (02), enzyme release ( and lyso zyme) and neutrophil aggregation in the peripheral blood of eight healthy volunteers and eight patients with RA.

Although enzyme release was greater in patients with RA, no significant difference was found throughout the day, neither in control nor in patients. Similar results were obtained when studying neutrophil aggregation.

On the contrary, the superoxide production, determined at 8:00, 14:00 and 20:00 h, was 6.3 ± 0.5, 4.40±0.4 and 6.26±0.3, respectively, in patients with RA and 6.65±0.7, 4.7±0.7 and 7.27±0.4 in the controls. The values obtained at 14:00 h were significantly lower ({alpha}=0.01). There were no differences in the curve form between patients and controls.

KEY WORDS: Rheumatoid arthritis, Circadian variations, Neutrophils


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.