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© 1991 British Society for Rheumatology

case-report

AUTOIMMUNE DISEASE AND HTLV-1 INFECTION

P. BOWNESS*, K. A. A. DAVIES*, J. TOSSWILL{dagger}, C. C. BUNN*, L. MAcALPINE{ddagger}, J. N. WEBER{dagger} and M. J. WALPORT*,

*Rheumatology Department of Medicine, Hanimersmith Hospital and Royal Postgraduate Medical School London W12
{dagger}Infectious Diseases Units Department of Medicine, Hanimersmith Hospital and Royal Postgraduate Medical School London W12
{ddagger}Virus Reference Laboratory, Central Public Health Laboratory London NW9 5HT

Correspondence to: Correspondence to Dr M. Walport, Rheumatology Unit, Hammersmith Hospital, Du Cane Road, London W12 ONN.

We describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be seropositive for HTLV-1 infection. We found no evidence of HTLV-1 infection ix 20 other patients known to have antibodies to U1RNP or in 36 British and West German patients with idiopathic adult polymyositis. In addition the serum from 20 anti-HTLV-1 positive patients did not contain antinuclear antibodies or antibodies to U1RNP. We conclude that rheumatological disease is associated with HTLV-1 through geographical rather than aetiological means.

KEY WORDS: HTLV-1, Mixed connective tissue disease, U1RNP


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