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© 1991 British Society for Rheumatology

other

INTERLEUKIN-6 ACTIVITY IN PAIRED SAMPLES OF SYNOVIAL FLUID. CORRELATION OF SYNOVIAL FLUID INTERLEUKIN—6 LEVELS WITH CLINICAL AND LABORATORY PARAMETERS OF INFLAMMATION

A. M. M. MILTENBURG, J. M. VAN LAAR, R. DE KUIPER, M. R. DAHA* and F. C. BREEDVELD

*Departments of Nephrology, University Hospital Leiden, The Netherlands
Departments of Rheumatology, University Hospital Leiden, The Netherlands

Correspondence to: Correspondence to Dr A. M. M. Miltenburg, University Hospital, Department of Rheumatology, Building 1, C2—Q, PO Box 9600, 2300 RC Leiden, The Netherlands.

Paired synovial fluid (SF) samples obtained from the knees of 12 arthritis patients were studied to establish a relation between parameters of local inflammatory activity and SF interleukin—6 (IL—6) levels. Local disease activity was scored using joint temperature, swelling and pain as clinical parameters of inflammation. SF samples were assayed for laboratory parameters of inflammation such as leucocyte content, the percentage polymorphonuclear cells, the pH, and for immu—noglobulin levels (IgG, IgM). SF IL—6 concentrations were determined using the B9—bioassay. Within individual patients the local activity of inflammation as measured using clinical parameters was found to be related to the local SF IL—6 level. When considering the total group of patients, a correlation (P<0.001) was found between the clinical parameters of local inflammation and the SF IL—6 levels. Furthermore, IL—6 levels were found to correlate with leucocyte counts (P<0.02), the percentage of polymorphonuclear cells (P<0.10), the pH value (P<0.01), but not with SF IgM and IgG concentrations.

KEY WORDS: Rheumatoid arthritis, Interleukin-6, Synovial fluid


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