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© 1991 British Society for Rheumatology

case-report

NON-INFECTIVE VERRUCOUS ENDOCARDITIS IN A PATIENT WITH ‘PRIMARY’ ANTIPHOSPHOLIPID SYNDROME

J. FONT, R. CARVERA*, C. PARÈ{dagger}, A. LÒPEZ-SOTO, L. PALLARÈS, M. AZQUETA{dagger} and M. A. KHAMASHTA*

Systemic Autoimmune Diseases Research Unit, Department of Internal Medicine, Hospital Clinic Barcelona, Spain
*Lupus Arthritis Research Unit, Rayne institute, St Thomas' Hospital London, UK
{dagger}Department of Cardiology, Hospital Clinic Barcelona, Spain

Correspondence to: Correspondence to: Dr J. Font. Servei de Medicina Interna General. Unitat 1. Hospital Clinic. Villarroel. 170. 08036 Barcelona. Spain

A 27-year-old women with ‘primary’ antiphospholipid syndrome, who developed a haemodynamically significant non-infective verrucous endocarditis is reported. Her mother suffered from antiphospholipid syndrome associated with systemic lupus erythematosus. A pathogenetic role of antiphospholipid antibodies in heart valve lesions is suggested.

KEY WORDS: Venous thrombosis, Lupus anticoagulant, Mitral valve thickening, Heart failure, Systemic lupus erythematosus


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