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© 1991 British Society for Rheumatology

case-report

ACQUIRED HYPOPROTHROMBINAEMIA AND LUPUS ANTICOAGULANT: RESPONSE TO STEROID THERAPY

R. J. HIFT, A. R. BIRD{dagger},{ddagger}{dagger} and B. D. SAREMBOCK*

*Departments of Medicine, University of Cape Town, and Groote Schuur Hospital Observatory, South Africa
{dagger}Departments of Haematology, University of Cape Town, and Groote Schuur Hospital Observatory, South Africa

Correspondence to: Correspondence to Dr R Hift. MRC/UCT Liver Research Centre. University of Cape Town. Medical School. Observatory. 7925. South Africa

An iliac crest bone marrow aspiration in a 24-year-old man was followed by severe haemorrhage into the iliopsoas muscle. A lupus anticoagulant and severe hypoprothrombinaemia, as well as clinical and laboratory pointers to suggest the presence of a systemic lupus erythematosus-like syndrome, were demonstrated. Therapy with prednisone was commenced following recurrent severe epistaxis. His prothrombin time, activated partial thromboplastin time and prothrombin activity improved promptly and his bleeding ceased. The lupus anticoagulant is commonly encountered in the laboratory, but acquired hypoprothrombinaemia is extremely rare. The condition is reviewed and its treatment discussed.

KEY WORDS: Systemic lupus erythematosus, Haemorrhage, Activated partial thromboplastin time, Prothrombin time, Treatment

{ddagger}{ddagger}Current address: Medical Director. Western Province Blood Transfusion Service. P.O. Box 3788. Cape Town. 8000. South Africa


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 LupusHome page
D Erkan, H Bateman, and M D Lockshin
Lupus anticoagulant-hypoprothrombinemia syndrome associated with systemic lupus erythematosus: report of 2 cases and review of literature
Lupus, September 1, 1999; 8(7): 560 - 564.
[Abstract] [PDF]


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