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© 1991 British Society for Rheumatology

research-article

ANTINUCLEAR ANTIBODIES IN FIRST-DEGREE RELATIVES OF PATIENTS WITH POLYMYOSITIS-DERMATOMYOSITIS: ANALYSIS OF THE RELATIONSHIP WITH HLA HAPLOTYPES

G. VALENTINI*,, R. D. G. IMPROTA*, M. RESSE{dagger}, S. MIGLIARESI*, P. B. MINUCCI{dagger}, R. TIRRI*, B. FARZATI{dagger} and G. TIRRI*

*Department of Medicine, Division of Rheumatology, University of Naples ‘Federico II’ Naples, Italy
{dagger}Institute of General Pathology, Chair of Immunohaematology, 1st Faculty of Medicine, University of Naples ‘Federico II’ Naples, Italy

Correspondence to: Correspondence to Dr G. Valentini, Department of Medicine, Division of Rheumatology, 1st Faculty of Medicine, Via S. Pansini 5, 80131 Naples, Italy

Antinuclear antibodies (ANA), as detected by indirect immunofluorescence on HEp-2 cells, have been investigated in five spouses and 41 first-degree relatives of nine probands with polymyositis-dermatomyositis (PM-DM) and in 41 sex- and age-matched controls. ANA were detected in 12 out of the 41 first-degree relatives and in two controls (x2=6.97; P<0.01).

HLA typing was done in four out of the nine families; in two of them only, ANA segregated with a haplotype. ANA positivity was not correlated either to sex or to age or to household contact. Our results show that ANA occur in a significant percentage of first-degree relatives of patients with PM-DM. The finding seems to be genetically conditioned.

KEY WORDS: Autoimmunity, Genetic factors, Connective tissue diseases


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