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© 1991 British Society for Rheumatology

other

MONOCLONAL ANTIBODY TREATMENT IN RHEUMATOID ARTHRITIS: THE CLINICAL AND IMMUNOLOGICAL EFFECTS OF A CD7 MONOCLONAL ANTIBODY

B. W. KIRKHAM, C. PITZALIS, G. H. KINGSLEY, I. C. CHIKANZA, S. SABHARWAL, C. BARBATIS*, R. GRAHAME, T. GIBSON, P. L. AMLOT{dagger} and G. S. PANAYI

Rheumatology Unit, United Medical and Dental Schools, Guy's Hospital London, England
*Department of Histopathology, Lewisham Hospital, and the Royal Free Hospital School of Medicine London, England
{dagger}Department of Immunology, The Royal Free Hospital School of Medicine London, England

Correspondence to: Correspondence to Professor G. Panayi, Rheumatology Unit, United Medical and Dental Schools, Guy's Hospital, London SE1 9RT

Six patients with rheumatoid arthritis were treated with a CD7 mouse monoclonal antibody, RFT2, daily for 14 days. Only two patients had a significant improvement in clinical disease activity which lasted 7–14 days. No serious adverse effects occurred although all patients developed antibodies against mouse immunoglobulin. During treatment T-lymphocyte numbers decreased and T-lymphocyte CD7 expression was absent in all but one patient.

KEY WORDS: Immunotherapy, Antigen modulation, RA


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