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© 1992 British Society for Rheumatology

other

THE EFFECT OF NASAL hCT ON BONE TURNOVER IN PAGET'S DISEASE OF BONE—IMPLICATIONS FOR THE TREATMENT OF OTHER METABOLIC BONE DISEASES

J. Y. REGINSTER*,{dagger}, A. M. JEUGMANS-HUYNEN*, M. WOUTERS*, N. SARLET*, H. D. MCINTYRE* and P. FRANCHIMONT*

*Bone Metabolism Unit, Department of Rheumatology and Endocrinology, University of Liège Liège, Belgium
{dagger}Georgetown University Medical Center Washington DC, USA

Correspondence to: Correspondence to J. Y. Reginster MD, Bone Metabolism Unit, CHU Brull (+9), Quai Godefroid Kurth 45, 4020 Liége, Belgium.

Thirty pagetic patients were treated for 6 months with a daily nasal application of 2 mg of synthetic human calcitonin (hCT). Serum alkaline phosphatases (SAP) and urinary hydroxyproline/creatinine ratio (OH/Cr), reflecting bone turn over, were significantly reduced from the first month of treatment (mean ± SEM: SAP, –13.9 ± 2.2%; OH/Cr, –22.2 ± 5.8%; both P.<0.01) and until the end of the 6-month course (mean ± SEM: SAP, –29.7 ± 4.6%; OH/Cr, –22.5 ± 5.9%; both P<0.01). Nasal hCT was perfectly tolerated both locally and systemically. These results allow us to consider nasal hCT for long-term trials in metabolic bone diseases characterized by a relative increase of bone resorption.

KEY WORDS: Paget's disease of bone, Calcitonin, Calcium, Osteoporosis


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