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© 1992 British Society for Rheumatology

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ANTILACTOFERRIN ANTIBODY IN SYSTEMIC LUPUS ERYTHEMATOSUS

S. S. LEE, J. W. M. LAWTON*, C. E. CHAN*, C. S. LI, T. H. KWAN and K. F. CHAU

Medical A. Unit, Queen Elizabeth Hospital Wylie Road, Kowloon, Hong Kong
*Department of Pathology, University of Hong Kong Pokfulam, Hong Kong

Correspondence to: Correspondence to Dr S. S. Lee

Lactoferrin is a secondary granule protein of neutrophils. Seventy-nine systemic lupus erythematosus patients who fulfilled the ARA criteria for classification were tested for antibody against human lactoferrin (LF-ab) by ELISA. Thirty-one of these (39.2%) demonstrated elevated levels. There was significant correlation between LF-ab positivity and disease duration. Clinical flare was common with positive LF-ab (P<0.05). Disease manifestations were independent of antibody status except for an increased incidence of lymphadenopathy and crescentic gomerulonephritis among those who had LF-ab. No consistent immunofluorescence pattern could be demonstrated on alcohol-fixed neutrophils for the LF-ab positive sera. It is suggested that LF-ab is related to lupus activity, and can be useful as a marker for disease monitoring.

KEY WORDS: ANCA, Anti-neutrophil cytoplasmic antibody, Disease activity, Lymphadenopathy, Glomerulonephritis


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