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© 1992 British Society for Rheumatology

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MOLECULAR MIMICRY IN THE PATHOGENESIS OF SPONDYLOARTHROPATHIES. A CRITICAL APPRAISAL OF CROSS-REACTIVITY BETWEEN MICROBIAL ANTIGENS AND HLA-B27

R. LAHESMAA*,, M. SKURNIK*, K. GRANFORS*, T. MÖTTÖNEN{dagger}, R. SAARIO{dagger}, A. TOIVANEN{dagger} and P. TOIVANEN*

*Department of Medical Microbiology, Turku University Turku, Finland
{dagger}Department of Medicine, Turku University Turku, Finland

Correspondence to: Correspondence to Dr R. Lahesmaa, Department of Medical Microbiology, Turku University, SF-20520 Turku, Finland

We describe an amino acid homology between a virulence plasmid encoded outer membrane protein of Yersinia, YadA (previously called Yop1) and HLA-B27. This tetrapeptide is also included in the hexapeptide, earlier found to be identical between Klebsiella nitrogenase and HLA-B27. The synthetic peptide based on the HLA-B27 homologous portion of the YadA does not stimulate lymphocytes obtained from HLA-B27+ patients with Yersinia-triggered reactive arthritis or from controls. One-third of the yersiniosis patients have antibodies against the synthetic peptide. Instead of recognizing the HLA-B27 homologous portion, the antibodies are directed against the left flanking sequence of the synthetic peptide. Similar results were obtained regarding antibody response to Klebsiella nitrogenase derived synthetic peptide included in the panel of controls; the response was not restricted to patients with reactive arthritis nor was it specifically directed against the sequence shared by HLA-B27 and Klebsiella pneumoniae nitrogenase. The present results do not support the role of molecular mimicry or cross-reactive antibodies in the pathogenesis of spondyloarthropathies.

KEY WORDS: Reactive arthritis, Yersinia, Klebsiella, HLA-B27, Molecular mimicry


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Home page
 Ann Rheum DisHome page
J H Ringrose
HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?
Ann Rheum Dis, October 1, 1999; 58(10): 598 - 610.
[Abstract] [Full Text]


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