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© 1992 British Society for Rheumatology


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IgG AND IgA ANTIBODY RESPONSES AGAINST PORINS IN YERSINIA-TRIGGERED REACTIVE ARTHRITIS

O. MÄKI-IKOLA*,{dagger}, J. L. HILL{dagger}, R. LAHESMAA{dagger}, A. TOIVANEN{ddagger} and K. GRANFORS{dagger},

*National Public Health Institute Turku
{dagger}Department of Medical Microbiology, Turku University Turku, Finland
{ddagger}Departments of Medicine, Turku University Turku, Finland

Correspondence to: Correspondence to K. Granfors, Department of Medical Microbiology, Turku University, SF-20520 Turku, Finland.

Using an enzyme immunoassay, the development and persistence of serum IgG and IgA class antibody responses against porins, a class of the major outer membrane proteins, were compared between patients who developed reactive arthritis and subjects who did not after Yersinia infection. A significant difference was seen between the two patient groups in the beginning of the disease: those with reactive arthritis had higher levels of IgG and IgA class antibodies against the porins. A similar difference in the IgA class antibodies was also seen at follow-up. This supports the hypothesis of persistence of the pathogen within the arthritic host.

KEY WORDS: Enzyme immunoassay, Outer membrane protein


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