© 1992 British Society for Rheumatology
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IgG AND IgA ANTIBODY RESPONSES AGAINST PORINS IN YERSINIA-TRIGGERED REACTIVE ARTHRITIS




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*National Public Health Institute Turku
Department of Medical Microbiology, Turku University Turku, Finland
Departments of Medicine, Turku University Turku, Finland
Correspondence to:
Correspondence to K. Granfors, Department of Medical Microbiology, Turku University, SF-20520 Turku, Finland.
Using an enzyme immunoassay, the development and persistence of serum IgG and IgA class antibody responses against porins, a class of the major outer membrane proteins, were compared between patients who developed reactive arthritis and subjects who did not after Yersinia infection. A significant difference was seen between the two patient groups in the beginning of the disease: those with reactive arthritis had higher levels of IgG and IgA class antibodies against the porins. A similar difference in the IgA class antibodies was also seen at follow-up. This supports the hypothesis of persistence of the pathogen within the arthritic host.
KEY WORDS: Enzyme immunoassay, Outer membrane protein
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