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© 1992 British Society for Rheumatology

case-report

FATAL NEUTROPENIC ENTEROCOLITIS ASSOCIATED WITH SULPHASALAZINE THERAPY FOR RHEUMATOID ARTHRITIS

K. CHAKRAVARTY*,, D. G. I. SCOTT* and B. G. MCCANN{dagger}

*Department of Rheumatology, Norfolk and Norwich Hospital Brunswick Road, Norwich NR1 3SR
{dagger}Department of Histopathology, Norfolk and Norwich Hospital Brunswick Road, Norwich NR1 3SR

Correspondence to: Correspondence to Dr K. Chakravarty

Neutropenia is a recognized complication of sulphasalazine therapy in patients with rheumatoid arthritis. It is usually mild, transient and rarely associated with serious sequelae. We describe a patient with rheumatoid arthritis who developed fatal neutropenic enterocolitis complicated by tracheo-oesophageal fistula following treatment with sulphasalazine.

KEY WORDS: Neutropenic enterocolitis, Rheumatoid arthritis, Sulphasalazine


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