Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by ISMAIEL, S.
Right arrow Articles by ELSON, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ISMAIEL, S.
Right arrow Articles by ELSON, C. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 British Society for Rheumatology

other

SUSCEPTIBILITY OF NORMAL AND ARTHRITIC HUMAN ARTICULAR CARTILAGE TO DEGRADATIVE STIMULI

S. ISMAIEL, R. M. ATKINS, M. F. PEARSE, P. A. DIEPPE and C. J. ELSON

Departments of Pathology and Microbiology, Orthopaedic Surgery and Rheumatology, University of Bristol

Correspondence to: Correpondence to Dr C. J. Elson, Department of Pathology and Microbiology, University of Bristol, Bristol BS8 111)

Recombinant interleukin-1 (IL-1) {alpha} and ß stimulated significant loss of glycosaminoglcan (GAG) content from normal (non-arthritic) articular cartilage explants but only after incubation for 14 days and only in specimens from 8/21 (38%) individuals. By contrast, all cartilage specimens but one from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) were degraded (as judged by their reduced GAG content) by the recombinant cytokines but again only after 14 days' incubation. The reduction in GAG induced by IL-1 was also greater for both OA and RA cartilage than normal cartilage. Synovial fluids (SFs) from RA patients stimulated greater loss of GAG content from OA cartilage explants than normal explants although in both cases the loss was evident within 2 days. It is concluded that cartilage explants from some individuals are susceptible to the degradative effects of IL-1 whereas others are refractory and that arthritic cartilage is more susceptible to degradation by both IL-1 and RA SFs than non-arthritic cartilage.

KEY WORDS: Interleukin-1, Synovial fluids, Degradation, Normal and arthritic cartilage explants


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
J B J van Meurs, P L E M van Lent, A A J van de Loo, A E M Holthuysen, E K Bayne, I I Singer, and W B van den Berg
Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis
Ann Rheum Dis, June 1, 1999; 58(6): 350 - 356.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.