© 1992 British Society for Rheumatology
research-article |
PROGNOSTIC FACTORS FOR RADIOGRAPHIC DAMAGE AND PHYSICAL DISABILITY IN EARLY RHEUMATOID ARTHRITIS. A PROSPECTIVE FOLLOW-UP STUDY OF 147 PATIENTS
*Department of Rheumatology, University Hospital Nijmegen The Netherlands
Department of Rheumatology, University Hospital Groningen The Netherlands
Department of Medical Statistics, Nijmegen University The Netherlands
Correspondence to:
Correspondence to Désirée M. F. M. van der Heijde, MD, Department of Rheumatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
We studied the influence of demographic, clinical, laboratory and genetic features and radiographic damage at onset on the outcome after 2 years in a prospective study of 147 patients with classical or definite RA with disease duration shorter than 1 year at entry. Outcome was determined by physical disability and by radiographic damage of hands and feet.
By means of multiple regression analysis and discriminant analysis outcome was explained from variables at the start and during the first 6 months. No clinically relevant conclusions could be made for physical disability due to the low explained variance and small number of patients with bad physical disability. Radiographic damage after 2 years was pre dicted by high disease activity at the start (measured as erythrocyte sedimentation rate, C-reactive protein or Disease Activity Score) combined with DR4 or DR2 (as a prognostically favourable factor) and rheumatoid factor positivity. Radiographic damage could be better predicted if disease activity during the first 6 months was included. Absence or pres ence of progression of radiographic damage could be correctly predicted in 83% of the patients.
KEY WORDS: Prognosis, Early rheumatoid arthritis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. RENESES, M. F. GONZALEZ-ESCRIBANO, A. FERNANDEZ-SUAREZ, L. PESTANA, B. DAVILA, I. WICHMANN, and A. GARCIA The Value of HLA-DRB1 Shared Epitope, -308 Tumor Necrosis Factor-{alpha} Gene Promoter Polymorphism, Rheumatoid Factor, Anti-Citrullinated Peptide Antibodies, and Early Erosions for Predicting Radiological Outcome in Recent-Onset Rheumatoid Arthritis J Rheumatol, June 1, 2009; 36(6): 1143 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P L C M van Riel, B Freundlich, D MacPeek, R Pedersen, J R Foehl, A Singh, and on behalf of ADORE study investigators Patient-reported health outcomes in a trial of etanercept monotherapy versus combination therapy with etanercept and methotrexate for rheumatoid arthritis: the ADORE trial Ann Rheum Dis, August 1, 2008; 67(8): 1104 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fontalba, V. Martinez-Taboada, O. Gutierrez, C. Pipaon, N. Benito, A. Balsa, R. Blanco, and J. L. Fernandez-Luna Deficiency of the NF-{kappa}B Inhibitor Caspase Activating and Recruitment Domain 8 in Patients with Rheumatoid Arthritis Is Associated with Disease Severity J. Immunol., October 1, 2007; 179(7): 4867 - 4873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Park, Weng Kee Wong, M. Oh, D. Khanna, R. H. Gold, J. T. Sharp, and H. E. Paulus Classifying radiographic progression status in early rheumatoid arthritis patients using propensity scores to adjust for baseline differences Statistical Methods in Medical Research, February 1, 2007; 16(1): 13 - 29. [Abstract] [PDF]
|
|
|
|
|
|
B Combe, R Landewe, C Lukas, H D Bolosiu, F Breedveld, M Dougados, P Emery, G Ferraccioli, J M W Hazes, L Klareskog, et al. EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) Ann Rheum Dis, January 1, 2007; 66(1): 34 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S M M Verstappen, J N Hoes, E J ter Borg, J W J Bijlsma, A A M Blaauw, G A van Albada-Kuipers, C van Booma-Frankfort, J W G Jacobs, and on behalf of the Utrecht Rheumatoid Arthritis Coho Joint surgery in the Utrecht Rheumatoid Arthritis Cohort: the effect of treatment strategy Ann Rheum Dis, November 1, 2006; 65(11): 1506 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X Le Loet, J M Berthelot, A Cantagrel, B Combe, M De Bandt, B Fautrel, R M Flipo, F Liote, J F Maillefert, O Meyer, et al. Clinical practice decision tree for the choice of the first disease modifying antirheumatic drug for very early rheumatoid arthritis: a 2004 proposal of the French Society of Rheumatology Ann Rheum Dis, January 1, 2006; 65(1): 45 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Goldbach-Mansky, S Suson, R Wesley, C E Hack, H S El-Gabalawy, and P P Tak Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis Ann Rheum Dis, May 1, 2005; 64(5): 715 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Morel, F Roch-Bras, N Molinari, J Sany, J F Eliaou, and B Combe HLA-DMA*0103 and HLA-DMB*0104 alleles as novel prognostic factors in rheumatoid arthritis Ann Rheum Dis, December 1, 2004; 63(12): 1581 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Forslind, M Ahlmen, K Eberhardt, I Hafstrom, and B Svensson Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP) Ann Rheum Dis, September 1, 2004; 63(9): 1090 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J van Aken, L R Lard, S le Cessie, J M W Hazes, F C Breedveld, and T W J Huizinga Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis Ann Rheum Dis, March 1, 2004; 63(3): 274 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Vittecoq, S. Pouplin, K. Krzanowska, F. Jouen-Beades, J. F. Menard, A. Gayet, A. Daragon, F. Tron, and X. Le Loet Rheumatoid factor is the strongest predictor of radiological progression of rheumatoid arthritis in a three-year prospective study in community-recruited patients Rheumatology, August 1, 2003; 42(8): 939 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Scott, C. Antoni, E. H. Choy, and P. C. L. M. van Riel Joint counts in routine practice Rheumatology, August 1, 2003; 42(8): 919 - 923. [Full Text] [PDF]
|
|
|
|
|
|
E Lindqvist, K Jonsson, T Saxne, and K Eberhardt Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis Ann Rheum Dis, July 1, 2003; 62(7): 611 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Meyer, C Labarre, M Dougados, P. Goupille, A Cantagrel, A Dubois, P Nicaise-Roland, J Sibilia, and B Combe Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage Ann Rheum Dis, February 1, 2003; 62(2): 120 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Berglin, R. Lorentzon, L. Nordmark, B. Nilsson-Sojka, and S. Rantapaa Dahlqvist Predictors of radiological progression and changes in hand bone density in early rheumatoid arthritis Rheumatology, February 1, 2003; 42(2): 268 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. G. Canvin, S. Bernatsky, C. A. Hitchon, M. Jackson, M. G. Sowa, J. R. Mansfield, H. H. Eysel, H. H. Mantsch, and H. S. El-Gabalawy Infrared spectroscopy: shedding light on synovitis in patients with rheumatoid arthritis Rheumatology, January 1, 2003; 42(1): 76 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Green, A. K. S. Gough, J. Devlin, J. Smith, P. Astin, D. Taylor, and P. Emery Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis Rheumatology, January 1, 2003; 42(1): 83 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L M A Jansen, D van Schaardenburg, I E van der Horst-Bruinsma, and B A C Dijkmans One year outcome of undifferentiated polyarthritis Ann Rheum Dis, August 1, 2002; 61(8): 700 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Aletaha, G Eberl, V P K Nell, K P Machold, and J S Smolen Practical progress in realisation of early diagnosis and treatment of patients with suspected rheumatoid arthritis: results from two matched questionnaires within three years Ann Rheum Dis, July 1, 2002; 61(7): 630 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Emery, F C Breedveld, M Dougados, J R Kalden, M H Schiff, and J S Smolen Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide Ann Rheum Dis, April 1, 2002; 61(4): 290 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Fransen, D Uebelhart, G Stucki, T Langenegger, M Seitz, and B A Michel The ICIDH-2 as a framework for the assessment of functioning and disability in rheumatoid arthritis Ann Rheum Dis, March 1, 2002; 61(3): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. van Everdingen, J. W.G. Jacobs, D. R. Siewertsz van Reesema, and J. W.J. Bijlsma Low-Dose Prednisone Therapy for Patients with Early Active Rheumatoid Arthritis: Clinical Efficacy, Disease-Modifying Properties, and Side Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ann Intern Med, January 1, 2002; 136(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L M A Jansen, I E van der Horst-Bruinsma, D van Schaardenburg, P D Bezemer, and B A C Dijkmans Predictors of radiographic joint damage in patients with early rheumatoid arthritis Ann Rheum Dis, October 1, 2001; 60(10): 924 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Katrib, P. P. Tak, J. V. Bertouch, C. Cuello, H. P. McNeil, T. J. M. Smeets, M. C. Kraan, and P. P. Youssef Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis Rheumatology, September 1, 2001; 40(9): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M C Albers, L Paimela, P Kurki, K B Eberhardt, P Emery, M A van `t Hof, F H J M Schreuder, M Leirisalo-Repo, and P L C M van Riel Treatment strategy, disease activity, and outcome in four cohorts of patients with early rheumatoid arthritis Ann Rheum Dis, May 1, 2001; 60(5): 453 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Harrison and D. Symmons Early inflammatory polyarthritis: results from the Norfolk Arthritis Register with a review of the literature. II. Outcome at three years Rheumatology, September 1, 2000; 39(9): 939 - 949. [Full Text] [PDF]
|
|
|
|
|
|
J. Huang, N. Stewart, J. Crabbe, E. Robinson, L. McLean, S. Yeoman, P. L. J. Tan, and F. M. McQueen A 1-year follow-up study of dynamic magnetic resonance imaging in early rheumatoid arthritis reveals synovitis to be increased in shared epitope-positive patients and predictive of erosions at 1 year Rheumatology, April 1, 2000; 39(4): 407 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L M A Jansen, D van Schaardenburg, I E van der Horst-Bruinsma, P D Bezemer, and B A C Dijkmans Predictors of functional status in patients with early rheumatoid arthritis Ann Rheum Dis, March 1, 2000; 59(3): 223 - 226. [Abstract] [Full Text]
|
|
|
|
|
|
T. R. D. J. Radstake, P. Barrera, J. M. C. Albers, H. L. Swinkels, L. B. A. van de Putte, and P. L. C. M. van Riel Familial vs sporadic rheumatoid arthritis (RA). A prospective study in an early RA inception cohort Rheumatology, March 1, 2000; 39(3): 267 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cranney, R. Goldstein, B. Pham, M. M Newkirk, and J. Karsh A measure of limited joint motion and deformity correlates with HLA-DRB1 and DQB1 alleles in patients with rheumatoid arthritis Ann Rheum Dis, November 1, 1999; 58(11): 703 - 708. [Abstract] [Full Text]
|
|
|
|
|
|
M. D. Posthumus, P. C. Limburg, J. Westra, H. A. Cats, R. E. Stewart, M. A. van Leeuwen, and M. H. van Rijswijk Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis Rheumatology, November 1, 1999; 38(11): 1081 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Möttönen, L Paimela, M Leirisalo-Repo, H Kautiainen, J Ilonen, and P Hannonen Only high disease activity and positive rheumatoid factor indicate poor prognosis in patients with early rheumatoid arthritis treated with "sawtooth" strategy Ann Rheum Dis, September 1, 1998; 57(9): 533 - 539. [Abstract] [Full Text]
|
|