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© 1992 British Society for Rheumatology

research-article

CYSTIC FIBROSIS ARTHRITIS. A REPORT OF FIVE CASES

E. PERTUISET*, C. J. MENKES*,, G. LENOIR{dagger}, M. JEHANNE{ddagger}, F. DOUCHAIN§ and M. GUILLOT

*Service de Rhumatologie, Hôpital Cochin Paris, France
{dagger}Service de Pédiatrie, Hôpital Necker-Enfants Malades Paris, France
{ddagger}Centre Hélio-Marin Roscoff, France
§Institut Albert Calmette, Camiers France
¶Service de Pédiatrie Lisieux, France

Correspondence to: Correspondence to professor C. J. Menkes, Service de Rhumatologie A, Höpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 paris, France

In a retrospective study of 206 patients with cystic fibrosis (CF), five cases of CF arthritis were recorded. This is a frequency of 2.5% and of 4.5% in patients aged over 10. Four patients had episodic arthritis, which was related to the course of pulmonary disease in two cases. In three patients, synovial fluid examination revealed minimal evidence of inflammation. In one of these three cases, synovial biopsy revealed a mild and non-specific synovitis. The fifth patient had chronic arthropathy and was positive for rheumatoid factor, but did not fulfil the criteria for rheumatoid arthritis. There were no radiographic abnormalities in any of these cases. CF arthritis is a rare syndrome of unknown pathogenesis.

KEY WORDS: Cystic fibrosis arthritis, Synovitis, Episodic arthritis


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