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© 1993 British Society for Rheumatology

research-article

PREVENTION OF COLLAGEN INDUCED ARTHRITIS IN MICE BY DELETION OF T CELL RECEPTOR Vß8 BEARING T CELLS WITH MONOCLONAL ANTIBODIES

K. G. MODER, H. S. LUTHRA, M. GRIFFITHS* and C. S. DAVID

Departments of Rheumatology and Immunology Mayo Clinic, Rochester, MN, USA
*Veterans Administration Medical Centre and University of Utah School of Medicine Salt Lake City, UT USA

Correspondence to: Correspondence to C. David, Department of Immunology, Mayo Clinic, Rochester MN 55905, USA

Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes Vß8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete Vß6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 4.66B5 treated animals was not significantly different from controls. Thus, the Vß8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.

KEY WORDS: Rheumatoid arthritis, Autoimmunity, Animal models of human disease


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