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© 1993 British Society for Rheumatology

case-report

SYSTEMIC-ONSET JUVENILE CHRONIC ARTHRITIS AND BONE MARROW HYPOPLASIA

A. K. EWER, P. J. DARBYSHIRE* and T. R. SOUTHWOOD

Childhood Arthritis Unit, Department of Rheumatology, University of Birmingham Vincent Drive, Edgbaston, Birmingham B15 2TT
*Department of Haematology, The Children's Hospital Ladywood Middleway, Ladywood, Birmingham B16 8ET

Correspondence to: Correspondence to: T. R. Southwood

A two-and-a-half-year-old girl with systemic-onset JCA developed pancytopaenia 21 days after her illness began. Bone marrow examination revealed hypoplasia, with no evidence of erythrophagocytosis. Two weeks later peripheral blood specimens showed evidence of bone marrow regeneration. No definite cause for the hypoplasia was found subsequently. Persistent haematological abnormalities after resolution of the hypoplasia included anaemia of chronic inflammation, leucocytosis and thrombocytosis. Unexplained bone marrow hypoplasia has not previously been described in systemic-onset JCA.

KEY WORDS: Systemic-onset JCA, Bone marrow hypoplasia, Pancytopaenia, JCA, Aplastic anaemia


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