© 1993 British Society for Rheumatology
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IDENTIFICATION OF THE 9G4 IDIOTOPE IN SYSTEMIC LUPUS ERYTHEMATOSUS
*Departments of Rheumatology Research, University College London Medical School London W1
Histopathology, University College London Medical School London W1
Molecular immunology Group, Southampton University Hospituls, Tenovus Laboratory Tremona Road, Southampton SO9 4XY
Correspondence to:
Correspondence to D. Isenberg, Bloomsbury Rheumatology Unit, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG
An idiotope designated 9G4 (9G4Id) is known to be a marker for immunoglobulins which utilize a particular VH gene, VH4–21. The idiotope has been found to be present on anti-DNA antibodies, and have been identified in 45% of sera from patients with SLE. This idiotope is strongly associated with lupus being very uncommon amongst the other autoimmune rheumatic diseases tested. This distinction is unlike virtually any of the other DNA antibody idiotypes described which are much more widely distributed. 9G4Id levels were found to fluctuate with disease activity in some lupus patients and this idiotope was detected in 3/11 SLE renal biopsies tested. Its presence is associated with the HLA markers A1 and B8 and raised 9G4Id levels are not simply a reflection of hypergammaglobulinaemia. Thus a new DNA antibody associated idiotope has been identified. Expression of the idiotope indicates that a notable proportion of anti-DNA antibodies have VH segments encoded by the same, or closely related genes, and that these restricted immunoglobulins are involved in the renal pathology found in SLE.
KEY WORDS: Idiotope, Systemic lupus erythematosus, DNA antibodies
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