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© 1993 British Society for Rheumatology

case-report

D-PENICILLAMINE AND POLYMYOSITIS: THE SIGNIFICANCE OF THE ANTI-JO-1 ANTIBODY

E. A. JENKINS, R. G. HULL and A. L. THOMAS

Department of Rheumatology, Queen Alexandra Hospital Cosham, Portsmouth PO6 3LY

A 57-yr-old lady developed polymyositis whilst taking D-penicillamine for RA. D-Penicillamine-induced polymyositis occurs in RA with a greater frequency than idiopathic polymyositis. Anti-acetyl choline receptor antibodies and ANA were positive, consistent with drug-induced disease. Anti-Jo-1 antibodies are considered specific for idiopathic myositis, and their presence was unexpected. Following withdrawal of the drug, the disappearance of the anti-Jo-1 and other antibodies coincident with clinical improvement, suggested that D-penicillamine was responsible for inducing antibody production.

KEY WORDS: Rheumatoid arthritis, Polymyositis, D-Penicillamine, Anti-Jo-1 antibody


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