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© 1993 British Society for Rheumatology

case-report

MYELOPEROXIDASE DEFICIENCY IN A PATIENT WITH RHEUMATOID ARTHRITIS: OXYGENATION AND RADICAL ACTIVITY BY PHAGOCYTIC CELLS

A. L. BELL, G. M. MARKEY*, H. D. ALEXANDER*, T. C. M. MORRIS*, S. A. McMILLAN{ddagger} and J. A. McNALLY

Department of Medicine (Rheumatology), School of Clinical Medicine, The Queen's University Belfast; Musgrave Park Hospital, Belfast
*Departments of Haematology Belfast City Hospital
{ddagger}Departments of lmmunology Belfast City Hospital

Correspondence to: Correspondence to A. L. Bell, Musgrave Park Hospital, Stockman's Lane, Belfast BT9 7JB

Complete functional deficiency of the phagocytic cell enzyme, myeloperoxidase, is described in a patient with rheumatoid arthritis. Measurement of oxygenation and free radical activity by blood monocytes and polymorphonuclear leucocytes shows gross reduction in myeloperoxidase-dependent chemiluminescence. Implications of these data for theories linking reactive oxygen species to inflammatory tissue damage in rheumatoid arthritis are discussed.

KEY WORDS: Rheumatoid arthritis, Reactive oxygen species, Cytochrome c, Myeloperoxidase, Chemiluminescence


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