Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HILLARBY, M. C.
Right arrow Articles by GRENNAN, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HILLARBY, M. C.
Right arrow Articles by GRENNAN, D. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 British Society for Rheumatology

other

UNUSUAL DQA-DR HAPLOTYPES IN RHEUMATOID VASCULITIS

M. C. HILLARBY, W. E. R. OLLIER*, M. DAVIS{ddagger}, J. DAVIDSON{ddagger}, P. A. SANDERS and D. M. GRENNAN

University of Manchesrer, Centre for Rheumatic Diseases, Hope Hospital Salford, M6 8HD
*ARC Epidemiology Research Unit Stopford Building, University of Manchester
{ddagger}Staffordshire Rheumarology Unit, Sroke on Trent
{ddagger}Regional Tissiie Typing Laboratory, St Mary's Hospital Manchester

Correspondence to: Correspondence to Dr D. Grennan, Reader in Rheumatology, University of Manchester

DQA and DQB variants and HLA haplotypes were defined in Caucasian subjects with rheumatoid arthritis (RA), in a rheumatoid subset characterized clinically by extra-articular features of major vasculitis, and in controls. DQ variants were defined using a panel of sequence specific oligonucleotide probes. In RA subjects without extra-articular features the frequency of DQB*0301 was significantly increased but this was secondary to the main association with DR4. In rheumatoid vasculitis by contrast, DQB*0302 rather than DQB*0301 was increased in frequency, in addition to an increase of C4A null alleles. Family studies showed that DR4 negative haplotypes had an increased frequency of unusual DR-DQA combinations as compared to other rheumatoid subsets. These findings are in keeping with the concept that genes within the MHC other than DR4 have a disease-modifying role in rheumatoid subsets. HLA haplotypes were defined in a family where the proband has RA and Felty's syndrome and an affected sister has rheumatoid vasculitis. These siblings share a DR4 bearing haplotype typing for DQB*0301, and the sister with rheumatoid vasculitis has a DR4 negative haplotype carrying a C4A null allele and an unusual DR-DQA combination.

KEY WORDS: MHC, Rheumatoid arthritis, HLA-DQA, HLA-DQB, HLA-DR


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
U. Wagner, S. Kaltenhauser, M. Pierer, W. Seidel, M. Troltzsch, H. Hantzschel, J. R. Kalden, and R. Wassmuth
Prospective analysis of the impact of HLA-DR and -DQ on joint destruction in recent-onset rheumatoid arthritis
Rheumatology, April 1, 2003; 42(4): 553 - 562.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.