© 1993 British Society for Rheumatology
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OSTEOARTHRITIC HUMAN CARTILAGE IS MORE SENSITIVE TO TRANSFORMING GROWTH FACTOR ß THAN IS NORMAL CARTILAGE
*Department of Rheumatology, University Hospital Utrecht Heidelberglaan 100, 3584CX Utrechi
Department of Rheumatology, University Hospital St Radboud Nijmegen, The Netherlands
Correspondence to:
Correspondence to: F. Lafeber, Department of Rheumatology, F02.223, University Hospital Utrecht, PO Box 85500, 3508GA Utrecht, The Netherlands
Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor ß (TGFß) a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGFß than normal healthy cartilage. This may indicate that TGFß plays an important role in the repair of osteoarthritic cartilage.
KEY WORDS: Osteoarthritis, Human, Cartilage, TGFß, Proteoglycans, Connective tissue
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