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© 1993 British Society for Rheumatology

other

PHYSIOLOGICAL VARIATIONS IN THE URINARY EXCRETION OF PYRIDINIUM CROSSLINKS OF COLLAGEN

A. M. McLAREN*,{dagger}, A. H. ISDALES{ddagger}, P. H. WHITING§, H. A. BIRDS{ddagger} and S. P. ROBINS*,

*Biochemical Sciences Division, Rowett Research Institute Aberdeen
{ddagger}Clinical Pharmacology Unit, Royal Bath Hospital Harrogare
§Department of Clinical Biochemistry, University of Aberdeen

Correspondence to: {dagger}Present address: ICI Biological Products, PO Box 1, Billingham, Cleveland TS23 1LB.

Correspondence to: Correspondence to: S. P. Robins, Biochemical Sciences Division, Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB

To further validate measurements of the pyridinium crosslinks of collagen as indices primarily of bone resorption in arthritis and other diseases, the effects of day-to-day and nyctohemeral|| variations, and of renal impairment have been studied. Day-to-day variations measured over 3 weeks were between 16 and 24% for a group of post-menopausal women. Nyctohemeral variations in crosslink excretion of 10–15% were recorded. Although crosslink excretion relative to creatinine was generally higher in the morning than in the evening, no consistent pattern was observed between healthy male and female volunteers and a group of patients with OA or RA. For patients with impaired renal function, with or without arthritis, there was no correlation between crosslink excretion and either creatinine clearance rates or urinary N-acetyl glucosaminidase activity. These results suggested that there was no direct relationship between renal function, at the glomerular or tubular level, and crosslink excretion.

KEY WORDS: Urinary pyridinium crosslinks, Pyridinoline, Deoxypyridinoline, Bone markers, Diurnal variation, Renal function

||The term ‘nyctohemeral’ rather than ‘diurnal’ is used to more correctly describe the changes that occur between the night and day-time periods


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