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© 1993 British Society for Rheumatology

other

AUTOANTIBODIES IN CENTRAL NERVOUS SYSTEM LUPUS

E. M. HAY and D. A. ISENBERG*

ARC Epidemiology Research Unit, University of Manchester Manchester
*Bloomsbury Rheumatology Unit, Department of Rheumatology Research, Universiry College and the Middlesex Hospital Medicol School London

Correspondence to: Correspondence to: E. M. Hay, ARC Epidemiology Research Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M9 3PT

Central nervous system (CNS) involvement in patients with lupus remains both a diagnostic and a therapeutic challenge. The role of autoantibodies in the pathogenesis of CNS lupus and/or as markers for disease activity is reviewed. Doubt is cast on the value of measuring anti-neuronal antibodies. Those antibodies binding ribosomal-P protein antigens or certain phospholipids appear to have greater utility, although even in these cases there is no uniform agreement as to their precise role in CNS disease induction, or how well antibody levels reflect disease activity.

KEY WORDS: Systemic lupus erythematosus, Neuropsychiatric, Autoantibodies


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