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© 1993 British Society for Rheumatology

brief-report

ANTIBODIES TO TYPE II COLLAGEN IN EARLY RHEUMATOID ARTHRITIS

K. MORGAN*,, R. B. CLAGUE{dagger}, I. REYNOLDS* and M. DAVIS{ddagger}

*Department of Rheumatology, University of Manchester Medical School
{dagger}Noble's Hospital Douglas, Isle of Man
{ddagger}The Staffordshire Rheumatology Centre, Stoke on Trent

Correspondence to: Correspondence to K. Morgan, Department of Rheumatology, University of Manchester Medical School, Oxford Road, Manchester M13 9PT

Antibodies to native and denatured type II collagen were investigated in a group of 79 patients with rheumatoid arthritis (RA) of disease duration less than 12 months (median 8 months; range 3–12 months). Using a solid-phase ELISA to measure these antibodies, the incidence of patients with levels above the upper limit of normal (mean of normal plus 3 SD) was low as compared to previous findings in patients with established disease. The majority of positive sera contained small amounts of IgM antibodies to denatured type II collagen whilst a few had IgG antibodies to native and denatured type II collagen.

These findings suggest that the production of high levels of serum anti-type II collagen antibodies in patients with RA is a secondary phenomenon, which may exacerbate the disease rather than be a primary cause of disease.

KEY WORDS: Collagen, Type II, Early rheumatoid arthritis, Antibodies


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