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© 1993 British Society for Rheumatology

research-article

RANITIDINE IN THE TREATMENT OF GASTRIC AND DUODENAL ULCERS ASSOCIATED WITH NON-STEROIDAL ANTI INFLAMMATORY DRUGS

G. TILDESLEY*, R. S. B. EHSANULLAH{dagger} and J. R. WOOD{dagger},

*Hartlepool General Hospital Hartlepool, Cleveland TS24 9AH
{dagger}Departrnent of Gastroenterology, Glaxo Group Research Limited Greenford, Middlesex UB6 0HE

Correspondence to: Correspondence to J. R. Wood

To assess the effect of 4 weeks' therapy with ranitidine 150 mg twice daily on the healing of symptomatic NSAID associated gastric and duodenal ulcers, 149 arthritic patients were randomly allocated to one of three treatment groups: ranitidine with NSAID continued, ranitidine with NSAID discontinued, and placebo with NSAID discontinued. The healing frequency in patients with gastric ulceration was 67, 68 and 47%, and in those with duodenal ulceration 61, 81 and 42%, respectively. Only the difference between the duodenal ulcer healing rates for ranitidine with NSAID discontinued and placebo was statistically significant (P=0.02). Healing rates were uninfluenced by gender, age, smoking habits, alcohol consumption, ulcer frequency or size, arthritic disease, or participating country.

KEY WORDS: Non-steroidal anti-inflammatory drug-associated ulcers, Ulcer healing, Ranitidine


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