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© 1993 British Society for Rheumatology

case-report

REVERSAL OF GOLD-INDUCED NEUTROPENIA WITH GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF)

D. A. COLLINS, J. H. TOBIAS, R. P. HILL and B. E. BOURKE

Department of Rheumatology, St George's Hospital Blackshaw Road, London SW17 OQT

We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colonystimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection. The patient suffered no side effects, and use of G-CSF represents an important addition to the management of a life-threatening drug reaction.

KEY WORDS: Rheumatoid arthritis, Sodium aurothiomalate, Marrow toxicity, Colony-stimulating factors


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