Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HILLARBY, M. C.
Right arrow Articles by SWINSON, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HILLARBY, M. C.
Right arrow Articles by SWINSON, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 British Society for Rheumatology

research-article

HLA ASSOCIATIONS IN SUBJECTS WITH RHEUMATOID ARTHRITIS AND BRONCHIECTASIS BUT NOT WITH OTHER PULMONARY COMPLICATIONS OF RHEUMATOID DISEASE

M. C. HILLARBY*, M. J. McMAHON*, D. M. GRENNAN*, R. G. COOPER*, R. W. E. CLARKSON*, E. J. DAVIES*, P. A. SANDERS*, C. CHATITOPADHYAY{dagger} and D. SWINSON{dagger}

*University of Manchester, Rheumatic Diseases Centre Hope Hospital, Salford M6 8HD
{dagger}University of Manchester, Department of Rheumatology, Wrightingion Hospital Lancashire

We have examined HLA-DR, DQA and DQB variants in 72 controls, 153 subjects with RA without extra-articular features and in subjects with the rheumatoid pulmonary complications of interstitial fibrosis (23) peripheral airways disease (13) and in 41 subjects with RA and bronchiectasis. Subjects with RA alone showed the expected association with HLA-DR4 (79%) but those with RA and co-existent pulmonary fibrosis were less likely to be DR4 positive (61%). No other HLA-DR variants were significantly increased in the different disease groups. HLA which types serologically as DQw1 was increased in subjects with RA and peripheral airways disease as compared to rheumatoid subjects with normal lung function, but these differences were not statistically significant. DQBI*0601 was increased in subjects with bronchiectasis with or without RA (but only significantly so in RA-BR subjects) DQBI*0301, DQBI*020l and DQAI*0501 frequencies were also increased in subjects with RA and bronchiectasis as compared to those with RA alone.

KEY WORDS: Rheumatoid arthritis, Pulmonary fibrosis, Obstructive airways disease, Bronchiectasis, HLA-DR, HLA-DQ, HLA-Dw, C4


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
E TOUSSIROT, J DESPAUX, and D WENDLING
Increased frequency of HLA-DRB1*0401 in patients with RA and bronchiectasis
Ann Rheum Dis, December 1, 2000; 59(12): 1001b - 1001.
[Full Text]

Home page
 ChestHome page
M. Cohen and S. A. Sahn
Bronchiectasis in Systemic Diseases
Chest, October 1, 1999; 116(4): 1063 - 1074.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
B. Cortet, T. Perez, N. Roux, R.-M. Flipo, B. Duquesnoy, B. Delcambre, and M. Rémy-Jardin
Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis
Ann Rheum Dis, October 1, 1997; 56(10): 596 - 600.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. PEREZ, M. REMY-JARDIN, and B. CORTET
Airways Involvement in Rheumatoid Arthritis . Clinical, Functional, and HRCT Findings
Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1658 - 1665.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.