Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by SOUTHWOOD, T. R.
Right arrow Articles by GASTON, J. S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SOUTHWOOD, T. R.
Right arrow Articles by GASTON, J. S. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 British Society for Rheumatology

case-report

EVOLUTION OF SYNOVIAL FLUID MONONUCLEAR CELL RESPONSES IN A HLA B27-POSITIVE PATIENT WITH YERSINIA- ASSOCIATED JUVENILE ARTHRITIIS

T. R. SOUTHWOOD and J. S. H. GASTON

Department of Rheumatology, University of Birmingham Birmingham B15 2TT

A 15-year-old boy who developed acute arthritis following an episode of urethritis, was found to have agglutinating anti bodies (titre 1:320) against Yersinia enterocolitica 0:3. Synovial fluid mononuclear cell (SFMC) proliferative responses to this agent and other antigens were examined on four occasions over the subsequent 40 months. Responses to Yersinia were predominant during the first year, but after 29 months responses to purified protein derivative of Mycobacterium tuberculosis and Salmonella were greater than to Yersinia. Moderate responses to a mycobacterial heat shock protein (HSP65) were present throughout the illness. These results suggest that maximal mononuclear cell proliferative responses may change overtime, and raise the possibility that responses which are initially specific for the inciting arthritogenic agent may eventually become more generalized.

KEY WORDS: Yersinia, Child, Juvenile arthritis, HLA B27


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.