© 1994 British Society for Rheumatology
research-article |
URINARY EXCRETION OF PYRIDINIUM CROSSLINKS OF COLLAGEN CORRELATED WITH JOINT DAMAGE IN ARTHRITIS
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*Clinical Pharmacology Unit, Royal Bath Hospital Harrogate, North Yorkshire HG1 2PS;
The Rowett Research Institute Bucksburn, Aberdeen AB2 9SB
Correspondence to:
H. A. Bird.
The urinary excretion of the collagen crosslinking compounds pyridinoline and deoxypyridinoline have been determined in patients with morphologically different subgroups of OA and RA. There was no significant difference in pyridinoline or deoxypyridinoline excretion when patients with four grades of severity of OA were compared, although the median excretion of pyridinoline and deoxypyridinoline for the OA group as a whole was raised above values found in a healthy control population. Patients with severe or late (burnt-out) RA were found to have a significantly greater excretion of pyridinoline and deoxypyridinoline than patients with early (<6 months duration) or mild RA.
KEY WORDS: Rheumatoid arthritis, Osteoarthritis, Pyridinoline, Collagen
Present address: ICI Biological Products Limited, P.O. Box 1, Billingham, Cleveland TS23 1LB.
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