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© 1994 British Society for Rheumatology

research-article

EARLY AGALACTOSYLATION OF IgG IS ASSOCIATED WITH A MORE PROGRESSIVE DISEASE COURSE IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A FOLLOW-UP STUDY

D. VAN ZEBEN*, G. A. W. ROOK{dagger}, J. M. W. HAZES*, A. H. ZWINDERMAN{ddagger}, Y. ZHANG{dagger}, S. GHELANI{dagger}, T. W. RADEMACHER§ and F. C. BREEDVELD*

*Departments of Rheumatology Leiden, The Netherlands
{dagger}Department of Medical Microbiology, School of Pathology, University College and Middlesex School of Medicine London
{ddagger}Departments of Medical Statistics University Hospital Leiden, The Netherlands
§Glycobiology Unit, Department of Biochemistry, University of Oxford Oxford

Correspondence to: D. van Zeben, University Hospital, Department of Rheumatology, Building 1, C4-R, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

The clinical significance of the percentage agalactosyl IgG oligosaccharides [%G(O)] was investigated in serum of a well-characterized cohort of 127 female RA patients who were followed for a mean duration of 6 yr. The %G(O) was determined in the first available serum sample which was obtained at a mean of 3.4 yr after symptom onset. It could be shown that patients with a %G(O) more than 2 S.D. above the mean level of controls (n = 34), had significantly more erosions, disease activity, and were treated with more second-line drugs, than patients without an increased %G(O) (n = 93), both at the time the serum sample was obtained, and during follow-up. These findings suggest that G(O) may serve as an indicator for the disease course in patients with RA.

KEY WORDS: Agalactosyl IgG, Prognosis, Outcome


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