© 1994 British Society for Rheumatology
research-article |
CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
*MRC Cyclotron Unit, Hammersmith Hospital Ducane Road, London W12 OHS
University of Manchester, Rheumatic Diseases Centre, Clinical Sciences Building, Hope Hospital Eccles Old Road, Salford M6 8HD
Department of Radiology, Kansai Medical University, 1 Fumizono-cho, Moriguchi, Osaka 570, Japan
Cyclotron and Radioisotopes Centre, Tohoku University Sendai 980, Japan
¶Department of Anaesthetics, Hammersmith Hospital Ducane Road, London W12 0HS
A group of four patients with RA were examined to test the hypothesis that there is a change in the endogenous opioid system in the brain during inflammatory pain. Regional cerebral opioid receptor binding was quantified using the opioid receptor antagonist [11C] diprenorphine and positron emission tomography (PET). In the four patients studied in and out of pain, significant increases in [11C]diprenorphine binding were seen in association with a reduction in pain. Increases were seen in most of the areas of the brain that were sampled apart from the occipital cortex. Significant region-specific increases over and above the more generalized changes were also seen in the frontal, cingulate and temporal cortices in addition to the straight gyrus. These findings are consistent with the hypothesis that there are substantial increases in occupancy by endogenous opioid peptides during inflammatory pain.
KEY WORDS: Rheumatoid arthritis, Pain, Inflammation, Positron emission tomograph, Opiate receptor, [11C] diprenorphine, Brain
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