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© 1994 British Society for Rheumatology

case-report

CIRRHOSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING LOW DOSE METHOTREXATE

G. CHANDRAN*, M. J. AHERN{dagger},, P de la M. HALL{ddagger}, R. GEDDES*, M. D. SMITH*, W. HILL* and J. H. HARLEY*

*Department of Medicine, Repatriation General Hospital Daw Park
{dagger}Department of Medicine, Flinders University of South Australia Bedford Park, South Australia
{ddagger}Department of Pathology, Flinders Medical Centre Bedford Park, South Australia

Correspondence to: Correspondence to: M. J. Ahern, Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042.

We describe three patients with RA who developed cirrhosis while taking low dose methotrexate (MTX). This report includes a review of the risk factors for cirrhosis occurring in association with MTX. Two of these patients were part of a prospective study to quantify changes in pericellular and total collagen in 76 patients with RA receiving low dose pulse MTX, giving a point prevalence of cirrhosis of 2.63%.

KEY WORDS: Rheumatoid arthritis, Methotrexate, Cirrhosis, Liver biopsy


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